This population-based cohort study analyzed 282,969 five-year survivors of adolescent and young adult (AYA) cancers diagnosed between 1975 and 2011, using SEER registry data. Over four decades, 5-year post-survival all-cause mortality decreased from 8.3% to 5.4%, primarily due to reductions in primary cancer mortality (6.8% to 4.2%). Significant improvements were
