This 2016 study assessed the effects of aging on immune response and melanoma-specific survival (MSS) using data from three large cohorts: SEER (n=304,476), IMCG (n=1,241), and TCGA (n=292). Results showed that older patients were more likely to present with thicker, ulcerated tumors and advanced-stage disease, leading to poorer MSS. However,
This population-based cohort study analyzed 282,969 five-year survivors of adolescent and young adult (AYA) cancers diagnosed between 1975 and 2011, using SEER registry data. Over four decades, 5-year post-survival all-cause mortality decreased from 8.3% to 5.4%, primarily due to reductions in primary cancer mortality (6.8% to 4.2%). Significant improvements were
This retrospective cohort study analyzed data from 54,635 women aged 70 and older to estimate breast cancer overdiagnosis associated with screening mammography. Findings revealed that overdiagnosis rates increased with age: 31% for ages 70–74, 47% for 75–84, and 54% for 85 and older. The study utilized Medicare claims linked to
