This study reports on the SCOTS trial, which utilized autologous bone marrow-derived stem cells (BMSCs) to treat patients with Leber's Hereditary Optic Neuropathy (LHON). Treatment methods included retrobulbar, subtenon, intravitreal, intra-optic nerve, subretinal, and intravenous injections of BMSCs. Patients experienced visual acuity improvements, with gains up to 35 letters on