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Tag: mitochondrial disease

Stem Cell Ophthalmology Treatment Study (SCOTS): Bone Marrow-Derived Stem Cells in the Treatment of Leber’s Hereditary Optic Neuropathy

This study reports on the SCOTS trial, which utilized autologous bone marrow-derived stem cells (BMSCs) to treat patients with Leber’s Hereditary Optic Neuropathy (LHON). Treatment methods included retrobulbar, subtenon, intravitreal, intra-optic nerve, subretinal, and intravenous injections of BMSCs. Patients experienced visual acuity improvements, with gains up to 35 letters on

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June 26, 2025 No Comments

Biomarkers of mitochondrial disorders

This systematic review evaluates mitochondrial biomarkers, highlighting GDF-15 and FGF-21 as the most promising candidates for diagnosing and managing mitochondrial disorders. Although these biomarkers demonstrate potential, their reliability varies across conditions, underscoring the need for further validation. Improved biomarker validation would enable earlier detection, better disease monitoring, and more precise

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June 26, 2025 No Comments

The Biochemical Assessment of Mitochondrial Respiratory Chain Disorders

This systematic review evaluates established and emerging biochemical markers for diagnosing mitochondrial respiratory chain (MRC) disorders, highlighting the potential of fibroblast growth factor-21 (FGF-21) and oxidative stress indicators. Traditional markers such as lactate and pyruvate remain important, but newer biomarkers may improve diagnostic accuracy. Challenges include a lack of standardized

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June 26, 2025 No Comments