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Tag: optic neuropathy

Stem Cell Ophthalmology Treatment Study (SCOTS): Bone Marrow-Derived Stem Cells in the Treatment of Leber’s Hereditary Optic Neuropathy

This study reports on the SCOTS trial, which utilized autologous bone marrow-derived stem cells (BMSCs) to treat patients with Leber’s Hereditary Optic Neuropathy (LHON). Treatment methods included retrobulbar, subtenon, intravitreal, intra-optic nerve, subretinal, and intravenous injections of BMSCs. Patients experienced visual acuity improvements, with gains up to 35 letters on

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June 26, 2025 No Comments

A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy

This 2011 multicenter, double-blind, randomized, placebo-controlled trial evaluated the efficacy and safety of idebenone (900 mg/day) over 24 weeks in 85 patients with Leber’s hereditary optic neuropathy (LHON) carrying the m.3460G>A, m.11778G>A, or m.14484T>C mitochondrial DNA mutations. The primary endpoint—best recovery in visual acuity—did not reach statistical significance in the

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June 26, 2025 No Comments

Methylene blue prevents neurodegeneration caused by rotenone in the retina

This study explored the neuroprotective effects of methylene blue against retinal neurodegeneration induced by rotenone, a mitochondrial complex I inhibitor. In a mouse model, intravitreal injection of methylene blue was shown to prevent retinal ganglion cell degeneration in a dose-dependent manner. The study demonstrated that methylene blue acts as an

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June 26, 2025 No Comments