This 2022 case report details the treatment of a 69-year-old female patient with primary Sjögren syndrome (SS) using oxygen-ozone autohemotherapy (O2-O3-AHT). The patient, presenting with ocular dryness, fatigue, and pain, underwent two cycles of three O2-O3-AHT sessions between December 2020 and January 2021. Post-treatment, she experienced rapid symptom relief without