This 2016 review article provides a comprehensive overview of antisynthetase syndrome (ASS), an autoimmune condition characterized by the presence of anti-aminoacyl tRNA synthetase antibodies, most commonly anti-Jo-1. Clinical manifestations include interstitial lung disease (ILD), myositis, arthritis, Raynaud’s phenomenon, and “mechanic’s hands.” ILD is notably more prevalent and severe in ASS
This 2014 multicenter clinical trial assessed the safety and efficacy of allogeneic umbilical cord mesenchymal stem cell transplantation (UC-MSCT) in 40 patients with active and refractory systemic lupus erythematosus (SLE). Patients received intravenous infusions of UC-MSCs on days 0 and 7. The treatment was well tolerated, with no transplantation-related adverse
This 2022 case report details the treatment of a 69-year-old female patient with primary Sjögren syndrome (SS) using oxygen-ozone autohemotherapy (O2-O3-AHT). The patient, presenting with ocular dryness, fatigue, and pain, underwent two cycles of three O2-O3-AHT sessions between December 2020 and January 2021. Post-treatment, she experienced rapid symptom relief without
This phase 1b/2a multicenter, open-label trial evaluated Descartes-08, an autologous RNA-engineered anti-BCMA CAR T-cell therapy, in 14 adults with generalized myasthenia gravis (MG). Unlike conventional DNA-based CAR T therapies, Descartes-08 utilizes transient mRNA expression, eliminating the need for lymphodepletion. Participants received up to six weekly infusions. The therapy was well
This large-scale, randomized, double-blind, placebo-controlled trial investigated whether daily supplementation with vitamin D₃ (2000 IU) and/or marine omega-3 fatty acids (1000 mg) reduces the incidence of autoimmune diseases. Over a median follow-up of 5.3 years among 25,871 U.S. adults aged ≥50 (men) and ≥55 (women), vitamin D supplementation led to
This case report describes the use of low-dose naltrexone (LDN) in a patient with systemic sclerosis experiencing severe pruritus unresponsive to conventional treatments. Administration of LDN at 4.5 mg nightly resulted in significant improvement in pruritus intensity and sleep quality within two weeks, with sustained benefits over several months. The
This study explored the effects of ozone therapy on Th17 cells in patients with multiple sclerosis (MS), revealing that the therapy induced significant changes in the frequency and function of these cells, which play a key role in the inflammatory processes of MS. The results suggest that ozone therapy may
This randomized controlled trial investigated the use of curcuminoids, compounds derived from turmeric, in patients with oral lichen planus (OLP), a chronic autoimmune condition affecting the oral mucosa. The study found that curcuminoid treatment significantly reduced OLP symptoms compared to baseline, with no major adverse effects reported, indicating good tolerability.
This 2021 observational study from the International Journal of Environmental Research and Public Health (PMID: 33925359) examined gut microbiota composition, intestinal permeability, diet, and cytokine levels in Brazilian patients with relapsing-remitting multiple sclerosis (RRMS) on disease-modifying therapies. Compared to healthy controls, RRMS patients showed gut dysbiosis with increased Akkermansia muciniphila
This case report discusses a 63-year-old Italian woman with rheumatoid arthritis (RA) who was found to have elevated levels of aluminum, cadmium, and lead. She underwent metal chelation therapy, which resulted in significant clinical improvement of her RA symptoms, suggesting a possible link between heavy metal exposure and autoimmune diseases.
