Well Referenced

Tag: Postmenopausal Hormone Therapy

Sedative and hypnotic effects of oral administration of micronized progesterone may be mediated through its metabolites

This study examined the sedative and hypnotic effects of orally administered micronized progesterone in eight postmenopausal women. A 400 mg dose induced a hypnotic state lasting approximately two hours in one participant, while serum levels of progesterone and its metabolites peaked between 2 to 6 hours post-administration. The study identified

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June 26, 2025 No Comments

Postmenopausal hormone therapy and risk of breast cancer

This review examines the relationship between postmenopausal hormone therapy (HT) and breast cancer risk, analyzing data from various studies. Findings suggest that combined estrogen-progestogen therapy is associated with a higher risk of breast cancer than estrogen-only therapy, with risk increasing with duration of use and decreasing after discontinuation. The type

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June 26, 2025 No Comments

Baseline associations between postmenopausal hormone therapy and inflammatory, haemostatic, and lipid biomarkers of coronary heart disease. The Women’s Health Initiative Observational Study

This study from the Women’s Health Initiative Observational Study examined how postmenopausal hormone therapy (PHT) affects biomarkers associated with coronary heart disease (CHD). Results showed that PHT use is linked to increased CRP, HDL, and triglyceride levels, as well as lower tPA-antigen and homocysteine. Estrogen plus progestin use was associated

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June 26, 2025 No Comments

Effect of postmenopausal hormones on inflammation-sensitive proteins: the Postmenopausal Estrogen/Progestin Interventions (PEPI) Study

This clinical trial investigated the effect of postmenopausal hormone therapy (HRT) on inflammation-sensitive proteins, which are known to predict cardiovascular disease outcomes. The study found that HRT significantly reduced these proteins, suggesting a potential mechanism for lowering cardiovascular risk in postmenopausal women. However, the effect was dependent on the type

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June 26, 2025 No Comments