Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose

This study investigated the effects of thiamine and benfotiamine on glucose metabolism in vascular cells cultured in high glucose conditions. Both thiamine and benfotiamine significantly reduced aldose reductase activity, sorbitol accumulation, and intracellular glucose levels while increasing transketolase activity, thereby promoting the pentose phosphate pathway. These findings suggest that thiamine