This 2020 retrospective study evaluated 8,606 intravenous (IV) push thiamine administrations in 2,595 adult patients at a tertiary academic medical center. Doses ranged from 100 mg to 500 mg, with the majority administered peripherally. The study found no instances of anaphylaxis or anaphylactoid reactions. Injection site reactions were rare, occurring
This article proposes that thiamine (vitamin B1) supplementation may serve as a preventive strategy against Alzheimer’s disease (AD) in elderly individuals who are cognitively normal but exhibit amyloid or tau deposition. Thiamine deficiency is common in older adults and is associated with several AD-related pathologies, including synaptic hypometabolism, mitochondrial dysfunction,
This study investigated the effects of thiamine and benfotiamine on glucose metabolism in vascular cells cultured in high glucose conditions. Both thiamine and benfotiamine significantly reduced aldose reductase activity, sorbitol accumulation, and intracellular glucose levels while increasing transketolase activity, thereby promoting the pentose phosphate pathway. These findings suggest that thiamine
This review article explores the therapeutic potential of benfotiamine, a lipid-soluble derivative of thiamine (vitamin B1), highlighting its superior bioavailability and its ability to activate transketolase—an enzyme that diverts harmful glycolytic intermediates from pathways that lead to advanced glycation end products (AGEs), a key factor in diabetic vascular complications. Benfotiamine
This observational study assessed the functional status of B vitamins—B6 (pyridoxine), B2 (riboflavin), and B1 (thiamine)—in patients with chronic fatigue syndrome (CFS) compared to healthy controls. Using red blood cell enzyme assays, the study found significantly reduced enzyme activity levels in CFS patients (p
A double-blind, placebo-controlled clinical trial examined the effects of vitamin B1 on premenstrual syndrome (PMS) symptoms among 80 students at Jahrom University of Medical Sciences. Participants were randomly assigned to receive either vitamin B1 or a placebo. The study found that vitamin B1 significantly reduced both mental (35.08%) and physical
