Pharmacokinetics and safety of intravenously administered citrulline in children undergoing congenital heart surgery: potential therapy for postoperative pulmonary hypertension

This study evaluated the safety and pharmacokinetics of intravenous citrulline in infants and children undergoing congenital heart surgery. In Phase 1, a dose-escalation protocol (50, 100, 150 mg/kg) was used, with a target plasma citrulline trough of 80–100 µmol/L. The 150 mg/kg dose achieved this target. Due to citrulline's short