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Tag: continuous infusion

Pharmacokinetics and safety of intravenously administered citrulline in children undergoing congenital heart surgery: potential therapy for postoperative pulmonary hypertension

This study evaluated the safety and pharmacokinetics of intravenous citrulline in infants and children undergoing congenital heart surgery. In Phase 1, a dose-escalation protocol (50, 100, 150 mg/kg) was used, with a target plasma citrulline trough of 80–100 µmol/L. The 150 mg/kg dose achieved this target. Due to citrulline’s short

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June 26, 2025 No Comments

Growth hormone (GH) profiles in response to continuous subcutaneous infusion of GH-releasing hormone(1-29)-NH2 in children with GH deficiency

This randomized controlled trial investigated the effects of continuous subcutaneous infusion of GH-releasing hormone(1-29)-NH2 (GHRH1-29-NH2) in children with growth hormone deficiency (GHD). The treatment successfully restored physiological growth hormone (GH) secretion patterns, leading to increased insulin-like growth factor 1 (IGF-1) levels and improved growth velocity. These results suggest that GHRH1-29-NH2

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June 26, 2025 No Comments