Methylene blue attenuates traumatic brain injury-associated neuroinflammation and acute depressive-like behavior in mice

This study highlights the neuroprotective effects of methylene blue (MB) in various brain injury models. MB was shown to reduce neuroinflammation and improve neurological function in traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) models. It achieved these effects through modulation of inflammatory pathways, particularly the Akt/GSK-3β/MEF2D signaling pathway. MB