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Tag: subarachnoid hemorrhage

Methylene blue attenuates neuroinflammation after subarachnoid hemorrhage in rats through the Akt/GSK-3β/MEF2D signaling pathway

This study evaluated the neuroprotective effects of methylene blue (MB) in rats following subarachnoid hemorrhage (SAH), focusing on its ability to reduce neuroinflammation. MB treatment significantly decreased brain edema and improved neurological function by activating the Akt/GSK-3β/MEF2D signaling pathway, which led to increased nuclear MEF2D levels. Additionally, MB reduced pro-inflammatory

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June 26, 2025 No Comments

Methylene blue attenuates traumatic brain injury-associated neuroinflammation and acute depressive-like behavior in mice

This study highlights the neuroprotective effects of methylene blue (MB) in various brain injury models. MB was shown to reduce neuroinflammation and improve neurological function in traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) models. It achieved these effects through modulation of inflammatory pathways, particularly the Akt/GSK-3β/MEF2D signaling pathway. MB

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June 26, 2025 No Comments