Long-term high-dose L-arginine supplementation in patients with vasculogenic erectile dysfunction: a multicentre, double-blind, randomized, placebo-controlled clinical trial

This 2022 multicenter, double-blind, randomized, placebo-controlled trial evaluated the effects of high-dose L-arginine (6 g/day) over 3 months in 98 men with vasculogenic erectile dysfunction (ED). L-arginine significantly improved International Index of Erectile Function-6 (IIEF-6) scores in both mild-moderate and severe ED groups. Peak systolic velocity (PSV) improvements were significant