This 2019 study investigates the role of the thioredoxin system in protecting malignant B-cells from oxidative stress induced by pharmacological ascorbate (vitamin C). The researchers found that inhibiting thioredoxin-dependent hydrogen peroxide (H₂O₂) removal sensitizes these cancer cells to ascorbate-induced cytotoxicity. By disrupting the thioredoxin system, the accumulation of H₂O₂ leads
