This 2016 meta-analysis evaluated the efficacy of hyperbaric oxygen therapy (HBOT) in patients with traumatic brain injury (TBI). Analyzing eight prospective studies encompassing patients with mild to severe TBI, the study found that HBOT significantly improved Glasgow Coma Scale (GCS) scores (mean difference: 3.13; 95% CI: 2.34–3.92; P < 0.001),