EDTA Chelation Therapy Alone and in Combination with Oral High-Dose Multivitamins and Minerals for Coronary Disease: The Factorial Group Results of the Trial to Assess Chelation Therapy

This randomized, double-blind, placebo-controlled, 2×2 factorial trial investigated the independent and combined effects of intravenous disodium EDTA chelation therapy and high-dose oral multivitamins/minerals (OMVM) in 1,708 patients with a history of myocardial infarction. Participants were randomized into four groups receiving: (1) EDTA + OMVM, (2) EDTA + placebo vitamins, (3)