cardiovascular prevention Archives

High-Dose Atorvastatin Is Superior to Moderate-Dose Simvastatin in Preventing Peripheral Arterial Disease

This post hoc analysis of the IDEAL trial examined 8,888 patients with prior myocardial infarction randomized to high-dose atorvastatin (80 mg/day) or moderate-dose simvastatin (20–40 mg/day) over a median of 4.8 years. Results showed a significantly lower incidence of peripheral arterial disease (PAD) in the atorvastatin group (2.2%) compared to

June 26, 2025 No Comments

Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

The VITamin D and OmegA-3 TriaL (VITAL) was a randomized, placebo-controlled trial involving 25,871 U.S. adults (men ≥50 years, women ≥55 years) with no prior history of cancer or cardiovascular disease. Participants received either 2,000 IU/day of vitamin D₃ or placebo for a median of 5.3 years. The trial found

June 26, 2025 No Comments

The Trial to Assess Chelation Therapy 2 (TACT2): Rationale and Design

This article presents the design and rationale of the TACT2 trial, a randomized, double-blind, placebo-controlled study aiming to confirm the cardiovascular benefits of EDTA chelation therapy observed in diabetic patients in the original TACT trial. Targeting a high-risk population of 1,200 patients with diabetes and prior myocardial infarction, the trial

June 26, 2025 No Comments

EDTA Chelation Therapy Alone and in Combination with Oral High-Dose Multivitamins and Minerals for Coronary Disease: The Factorial Group Results of the Trial to Assess Chelation Therapy

This randomized, double-blind, placebo-controlled, 2×2 factorial trial investigated the independent and combined effects of intravenous disodium EDTA chelation therapy and high-dose oral multivitamins/minerals (OMVM) in 1,708 patients with a history of myocardial infarction. Participants were randomized into four groups receiving: (1) EDTA + OMVM, (2) EDTA + placebo vitamins, (3)

June 26, 2025 No Comments

MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults

This study analyzed the relationship between the MTHFR gene polymorphism (C677T) and cardiovascular risks in a Chinese population with low folate intake. It found that individuals with the TT genotype had a significantly higher risk of stroke and heart disease compared to those with the CC genotype. The findings suggest

June 26, 2025 No Comments

CT calcium scoring. History, current status and outlook

This article reviews coronary artery calcium scoring using CT imaging, particularly the Agatston scoring system, which helps assess cardiovascular risk. The technique quantifies coronary artery calcium, a marker for coronary atherosclerosis, and has been correlated with cardiovascular events, even in asymptomatic patients. It discusses the clinical relevance of this non-invasive

June 26, 2025 No Comments

Association of Physical Activity With Risk of Mortality and Cardiovascular Disease in 130,000 People in the UK Biobank Study

This cohort study from the UK Biobank analyzed the relationship between physical activity and the risk of mortality and cardiovascular disease (CVD) in 130,000 participants. It found that even small amounts of exercise, such as 150 minutes per week, significantly reduced the risk of death from all causes and CVD,

June 26, 2025 No Comments

Well Referenced

Tag: cardiovascular prevention

High-Dose Atorvastatin Is Superior to Moderate-Dose Simvastatin in Preventing Peripheral Arterial Disease

Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

The Trial to Assess Chelation Therapy 2 (TACT2): Rationale and Design

EDTA Chelation Therapy Alone and in Combination with Oral High-Dose Multivitamins and Minerals for Coronary Disease: The Factorial Group Results of the Trial to Assess Chelation Therapy

MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults

CT calcium scoring. History, current status and outlook

Association of Physical Activity With Risk of Mortality and Cardiovascular Disease in 130,000 People in the UK Biobank Study