This 2007 review examines the metabolic impacts of high-protein diets, particularly in weight-stable individuals. Findings indicate that higher protein intake is associated with lower blood pressure and, in diabetic patients, reduced glycosylated hemoglobin levels. However, the long-term effects on atherosclerosis risk remain unclear due to limited and conflicting epidemiological data.
This 2014 prospective study evaluated the effects of combining orlistat (120 mg three times daily) with lifestyle modifications (low-calorie diet and exercise) over six months in 101 women with PCOS and 29 BMI-matched controls. Both groups experienced significant BMI reductions. In the PCOS group, there were notable improvements in insulin
This 15-day randomized, double-blind, placebo-controlled trial evaluated the safety and efficacy of Hoodia gordonii purified extract (HgPE) in 49 healthy overweight women. Participants consumed 2 servings per day of 1110 mg HgPE or placebo in a yogurt drink. The HgPE group experienced adverse effects such as nausea, vomiting, and skin
This 2011 systematic review and meta-analysis evaluated the efficacy of isolated aerobic exercise programs in overweight and obese populations. Analyzing 14 randomized controlled trials encompassing 1,847 participants, the study found that moderate-intensity aerobic exercise over 6 to 12 months led to modest reductions in weight (approximately 1.6–1.7 kg) and waist
This 2014 review article examines the role of testosterone supplementation therapy (TST) in men with metabolic syndrome (MetS). MetS is characterized by a cluster of conditions including increased waist circumference, high triglyceride levels, low HDL cholesterol, high blood pressure, and insulin resistance, which collectively elevate the risk of type 2
This 2000 single-blind, controlled, crossover dietary intervention study investigated the effects of L-arginine supplementation on blood pressure and metabolic parameters in six healthy volunteers. Participants followed three isocaloric diets for one week each: a control diet, a diet enriched with L-arginine through natural foods, and the control diet supplemented with
This study evaluated the effects of a combined supplementation of Monacolin K (10 mg/day) and Coenzyme Q10 (30 mg/day) over 8 weeks in 40 patients with metabolic syndrome characterized by hypertension and hypercholesterolemia. The intervention led to significant reductions in systolic and diastolic blood pressure, total cholesterol, LDL cholesterol, and
This 8-week randomized controlled trial compared the effects of a moderately high protein diet (30% protein, 40% carbohydrate) versus a high fiber, high carbohydrate diet (50% carbohydrate, >35 g fiber, 20% protein) on weight loss and metabolic parameters in 83 overweight or obese women aged 18–65 with risk factors for
This multicenter European study aimed to establish reference and normal values for carotid-femoral pulse wave velocity (cf-PWV), a direct measure of aortic stiffness, by analyzing data from 16,867 subjects across 13 centers in eight countries. Among these, 11,092 individuals without overt cardiovascular disease, diabetes, or antihypertensive/lipid-lowering treatment constituted the reference
This 2005 randomized crossover trial by He et al. assessed the effects of potassium chloride (KCl) and potassium citrate (K-citrate) supplementation on blood pressure in 14 hypertensive individuals. Participants received 96 mmol/day of either KCl or K-citrate for one week each. Both supplements significantly reduced systolic and diastolic blood pressure
