This 2017 double-blind randomized controlled trial assessed the efficacy of glucosamine-chondroitin sulfate (GC) with and without methylsulfonylmethane (MSM) in 147 patients with Kellgren-Lawrence grade I-II knee osteoarthritis. Patients were randomized into three groups: GC (1500 mg glucosamine + 1200 mg chondroitin sulfate), GC plus MSM (GCM; same GC dose plus
