This 2018 in vitro study evaluated the effects of methylsulfonylmethane (MSM) on prostate cancer cell lines LNCaP, PC3, and DU-145. MSM treatment led to decreased cell viability and invasiveness by inducing apoptosis and causing cell cycle arrest at the G0/G1 phase. At a concentration of 200 mM, MSM significantly reduced
This 2018 review analyzed systematic reviews and randomized controlled trials to evaluate the efficacy of various oral supplements for osteoarthritis (OA). The findings indicate limited but promising evidence supporting the use of Boswellia serrata extract, Pycnogenol, curcumin, and methylsulfonylmethane (MSM) in alleviating OA symptoms. Despite the generally poor quality of
This 2017 double-blind randomized controlled trial assessed the efficacy of glucosamine-chondroitin sulfate (GC) with and without methylsulfonylmethane (MSM) in 147 patients with Kellgren-Lawrence grade I-II knee osteoarthritis. Patients were randomized into three groups: GC (1500 mg glucosamine + 1200 mg chondroitin sulfate), GC plus MSM (GCM; same GC dose plus
