Changes in lifestyle, biological risk factors and total homocysteine in relation to MTHFR C677T genotype: a 5-year follow-up study

This cohort study investigated the relationship between MTHFR C677T genotypes and changes in total homocysteine (tHcy) levels over five years in a population of 1,805 adults. It found that lifestyle changes such as diet and exercise did not significantly affect tHcy levels, but biological factors like waist circumference and cholesterol