This 2011 study from the GENDEP project compared weight changes in 630 adults with moderate-to-severe unipolar depression treated with either nortriptyline (a tricyclic antidepressant) or escitalopram (an SSRI) over 26 weeks. Nortriptyline users experienced significant weight gain, averaging 1.2 kg at 12 weeks, with continued increase over six months. Weight
