This 2011 study from the GENDEP project compared weight changes in 630 adults with moderate-to-severe unipolar depression treated with either nortriptyline (a tricyclic antidepressant) or escitalopram (an SSRI) over 26 weeks. Nortriptyline users experienced significant weight gain, averaging 1.2 kg at 12 weeks, with continued increase over six months. Weight
This 2014 guideline by the American Gastroenterological Association (AGA) provides evidence-based recommendations for the pharmacological treatment of irritable bowel syndrome (IBS) in adults. Utilizing the GRADE methodology, the guideline evaluates various medications for IBS subtypes. For IBS with constipation (IBS-C), it recommends linaclotide and lubiprostone. For IBS with diarrhea (IBS-D),
This systematic review summarizes the pharmacological treatments for panic disorder, highlighting the effectiveness of SSRIs, SNRIs, and benzodiazepines like clonazepam as first-line therapies. It also discusses newer agents such as inositol and duloxetine, as well as adjunctive therapies like cognitive behavioral therapy (CBT) combined with D-cycloserine. The review found that
This review discusses hormone replacement therapy (HRT) and estrogen replacement therapy (ERT) for women with a history of breast cancer, emphasizing the challenges and risks due to concerns about cancer recurrence. While HRT and ERT are effective for managing menopausal symptoms, the review highlights alternative treatments like SSRIs (e.g., venlafaxine),
