Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: how to become a 21st-century hunter-gatherer

This 2004 review by O'Keefe and Cordain explores the discordance between modern Western diets and lifestyles and the genetic makeup shaped during the Paleolithic era. The authors argue that the shift from a hunter-gatherer lifestyle to one characterized by processed foods, sedentary behavior, and chronic stress has contributed to the