Well Referenced

Tag: omega-3 fatty acids

Use of Oral Supplements and Topical Adjuvants for Isotretinoin-Associated Side Effects: A Narrative Review

This 2024 narrative review evaluates the efficacy and safety of various oral supplements and topical adjuvants in mitigating mucocutaneous and musculoskeletal side effects associated with isotretinoin therapy. Oral supplements such as omega-3 fatty acids, vitamin E, folic acid with vitamin B12, antihistamines, L-carnitine, biotin, and combination supplements were found to

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June 26, 2025 No Comments

Natural products, micronutrients, and nutraceuticals for the treatment of depression: A short review

This 2017 review article explores the potential of natural compounds, micronutrients, and nutraceuticals in managing depression. It highlights the limitations of conventional antidepressants, such as delayed onset and adverse effects, and discusses alternative treatments. The review examines various natural substances, including green tea catechins, anthocyanins, cocoa extracts, resveratrol, omega-3 fatty

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June 26, 2025 No Comments

Effects of Omega-3 Supplementation on Weight Loss and Body Composition

This 2011 randomized controlled trial assessed the impact of omega-3 fatty acid supplementation combined with dietary and exercise counseling on weight loss and body composition in overweight and obese adults. Over 24 weeks, participants in both the omega-3 and placebo groups lost more than 5% of their body weight. However,

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June 26, 2025 No Comments

Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: how to become a 21st-century hunter-gatherer

This 2004 review by O’Keefe and Cordain explores the discordance between modern Western diets and lifestyles and the genetic makeup shaped during the Paleolithic era. The authors argue that the shift from a hunter-gatherer lifestyle to one characterized by processed foods, sedentary behavior, and chronic stress has contributed to the

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June 26, 2025 No Comments

NAFLD and nutraceuticals: a review of completed phase III and IV clinical trials

This 2023 systematic review analyzed 12 completed phase III and IV clinical trials registered on ClinicalTrials.gov, focusing on nutraceutical interventions for Nonalcoholic Fatty Liver Disease (NAFLD). The majority of studies investigated vitamin D (26.7%) and omega-3 fatty acids (20.0%), with others examining caffeine, chlorogenic acid, ginger, phosphatidylcholine, Trigonella foenum-graecum seed

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June 26, 2025 No Comments

Vitamin D and Marine Omega-3 Fatty Acid Supplementation and Incident Autoimmune Disease: VITAL Randomized Controlled Trial

This large-scale, randomized, double-blind, placebo-controlled trial investigated whether daily supplementation with vitamin D₃ (2000 IU) and/or marine omega-3 fatty acids (1000 mg) reduces the incidence of autoimmune diseases. Over a median follow-up of 5.3 years among 25,871 U.S. adults aged ≥50 (men) and ≥55 (women), vitamin D supplementation led to

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June 26, 2025 No Comments

The Benefits of Marine Omega-3s for the Prevention and Treatment of Cardiovascular Disease

This narrative review explores the cardiovascular effects of marine omega-3 fatty acids, focusing on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Clinical evidence, particularly from the REDUCE-IT trial, demonstrates that high-dose EPA (4 g/day of icosapent ethyl) can significantly reduce major adverse cardiovascular events (MACE) by 25% in high-risk individuals.

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June 26, 2025 No Comments

Dietary and Nutraceutical Options for Managing the Hypertriglyceridemic Patient

This 2006 review by Harris and Kris-Etherton examines dietary and nutraceutical interventions for managing hypertriglyceridemia. The authors highlight that lifestyle modifications, including weight loss, reduced intake of saturated fats and simple carbohydrates, and increased physical activity, can significantly lower triglyceride levels. Nutraceuticals such as omega-3 fatty acids, niacin, and plant

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June 26, 2025 No Comments

Hypertriglyceridemia: Its Etiology, Effects and Treatment

This 2007 review by Yuan, Al-Shali, and Hegele provides a comprehensive overview of hypertriglyceridemia, focusing on its causes, clinical manifestations, and management strategies. The authors discuss both primary (genetic) and secondary (lifestyle or disease-related) factors contributing to elevated triglyceride levels. Clinical signs can include eruptive xanthomas and lipemia retinalis, with

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June 26, 2025 No Comments

Stuck at the bench: Potential natural neuroprotective compounds for concussion

This narrative review examines a range of natural compounds with potential neuroprotective effects in the context of concussion and mild traumatic brain injury (mTBI). Preclinical studies suggest that agents such as omega-3 fatty acids, curcumin, resveratrol, and green tea catechins exhibit anti-inflammatory, antioxidant, and neurorestorative properties that could mitigate post-concussive

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June 26, 2025 No Comments