Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro

This study investigates the synergistic effect of ascorbic acid (vitamin C) on the antineoplastic activity of common chemotherapy agents—doxorubicin, cisplatin, and paclitaxel—against human breast carcinoma cells. The findings demonstrate that ascorbic acid enhances the efficacy of these chemotherapeutic agents by improving their cytotoxic effects. This suggests that vitamin C could