This 2014 in vitro study assessed the effects of alpha-lipoic acid (ALA) on the proliferation of human colon (Caco-2) and cervical (HeLa) cancer cell lines. Using MTT assays, researchers evaluated ALA’s impact alone and in combination with chemotherapeutic agents cisplatin and 5-fluorouracil (5-FU). The study found that high concentrations of
This 2019 systematic review evaluated 13 studies involving 754 patients with muscle-invasive bladder cancer (MIBC) who received neoadjuvant chemotherapy with gemcitabine and cisplatin (GC) prior to radical cystectomy. The analysis demonstrated a complete pathological response (pT0) in 30% of patients and pathological downstaging to non–muscle-invasive disease (
This 1998 clinical trial evaluated the impact of oral glutamine supplementation (30 g/day for 28 days) on immune and gut barrier function in 13 patients with advanced esophageal cancer undergoing radiochemotherapy (5-fluorouracil and cisplatin with mediastinal irradiation). Compared to controls, the glutamine group maintained higher lymphocyte counts (1007 ± 151/mm³
This study investigates the synergistic effect of ascorbic acid (vitamin C) on the antineoplastic activity of common chemotherapy agents—doxorubicin, cisplatin, and paclitaxel—against human breast carcinoma cells. The findings demonstrate that ascorbic acid enhances the efficacy of these chemotherapeutic agents by improving their cytotoxic effects. This suggests that vitamin C could
The 2012 study “Glutamine: A novel approach to chemotherapy-induced toxicity” (DOI: 10.4103/0971-5851.96962) reviews the potential of glutamine supplementation to reduce the adverse effects of chemotherapy, such as mucositis, cardiotoxicity, neurotoxicity, and gastrointestinal damage. The study highlights glutamine’s protective role in supporting immune function, mitigating side effects, and enhancing recovery during
