The dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide: a novel cardiometabolic therapeutic prospect

This 2021 review by Fisman and Tenenbaum discusses tirzepatide, a dual GIP and GLP-1 receptor agonist, as an innovative treatment for type 2 diabetes and obesity. Clinical trials, notably the SURPASS program, have demonstrated that tirzepatide significantly reduces HbA1c levels and body weight in a dose-dependent manner, outperforming existing therapies