This systematic review and network meta-analysis evaluated the efficacy and safety of five FDA-approved long-term weight loss medications—phentermine-topiramate, liraglutide, naltrexone-bupropion, lorcaserin, and orlistat—in overweight and obese adults. Analyzing 28 randomized clinical trials encompassing 29,018 participants (median age 46 years; 74% women; median BMI 36.1), the study found that all medications
