Growth hormone (GH)-releasing peptide-6 requires endogenous hypothalamic GH-releasing hormone for maximal GH stimulation

This study examined the effects of growth hormone-releasing peptide-6 (GHRP-6) on growth hormone (GH) secretion in healthy male volunteers, demonstrating that GHRP-6 significantly stimulates GH release, with its effects largely dependent on the presence of endogenous growth hormone-releasing hormone (GHRH). When participants were pretreated with a GHRH antagonist, the GH