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Tag: growth hormone secretion

Growth hormone (GH)-releasing peptide-6 requires endogenous hypothalamic GH-releasing hormone for maximal GH stimulation

This study examined the effects of growth hormone-releasing peptide-6 (GHRP-6) on growth hormone (GH) secretion in healthy male volunteers, demonstrating that GHRP-6 significantly stimulates GH release, with its effects largely dependent on the presence of endogenous growth hormone-releasing hormone (GHRH). When participants were pretreated with a GHRH antagonist, the GH

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June 26, 2025 No Comments

Growth hormone and prolactin secretion after growth hormone-releasing hormone administration, in anorexia nervosa patients, normal controls and tamoxifen-pretreated volunteers

This study assessed the effects of growth hormone-releasing hormone (GHRH) on growth hormone (GH) and prolactin (PRL) secretion in women with anorexia nervosa, normal controls, and tamoxifen-pretreated volunteers. Results showed that GHRH administration induced a GH peak in both anorexia nervosa patients and controls, suggesting that the hypothalamic-pituitary axis remains

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June 26, 2025 No Comments

Growth hormone release by the novel GH releasing peptide hexarelin in patients with homozygous beta-thalassemia

This observational study investigated the effects of hexarelin, a growth hormone (GH) releasing peptide, on GH secretion in patients with homozygous beta-thalassemia, a genetic disorder often associated with growth retardation due to impaired GH secretion. The results showed that hexarelin effectively stimulated GH release, producing GH peaks comparable to those

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June 26, 2025 No Comments

Influence of dopaminergic, adrenergic and cholinergic blockade and TRH administration on GH responses to GRF 1-29

This study investigated the effects of dopaminergic, adrenergic, and cholinergic blockade, along with TRH administration, on growth hormone (GH) responses to growth hormone-releasing factor (GRF) 1-29. It was found that these neurotransmitter systems modulate GH secretion in response to GRF, and TRH administration also influenced GH release. The study highlights

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June 26, 2025 No Comments

Interaction of the growth hormone releasing peptide hexarelin with somatostatin

This study investigated the interaction between hexarelin, a growth hormone-releasing peptide, and somatostatin, which inhibits growth hormone (GH) release. The results showed that somatostatin and hexarelin counteract each other’s effects on GH secretion, with somatostatin inhibiting and hexarelin stimulating GH release. The combination of hexarelin with growth hormone-releasing hormone (GHRH)

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June 26, 2025 No Comments

Lack of effect of muscarinic cholinergic blockade on the GH responses to GRF 1-29 and TRH in acromegalic subjects

This study investigated the role of muscarinic cholinergic receptors in regulating growth hormone (GH) secretion in acromegalic patients. The trial involved eight subjects who received GH-releasing factor (GRF 1-29) and thyrotropin-releasing hormone (TRH) tests, with and without pirenzepine, a muscarinic antagonist. The results showed that muscarinic cholinergic blockade did not

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June 26, 2025 No Comments

Low-dose growth hormone-releasing hormone tests: a dose-response study

This clinical trial evaluated the dose-response relationship of GHRH(1-29)NH2 in stimulating growth hormone (GH) secretion in healthy adult males. The study found that both 10- and 100-microgram doses of GHRH(1-29)NH2 resulted in significant GH responses, with the 10-microgram dose eliciting a slower decline in GH levels, suggesting a more prolonged

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June 26, 2025 No Comments

Pharmacokinetics of growth hormone-releasing hormone(1-29)-NH2 and stimulation of growth hormone secretion in healthy subjects after intravenous or intranasal administration

This study examined the pharmacokinetics of growth hormone-releasing hormone (GHRH(1-29)-NH₂) and its ability to stimulate growth hormone (GH) secretion. The results showed that the administration of GHRH(1-29)-NH₂ significantly increased GH levels in participants, with a dose-dependent effect observed. This suggests that GHRH(1-29)-NH₂ could be a potential therapeutic agent for stimulating

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June 26, 2025 No Comments

Plasma GH responses to human GHRH-antagonist in normal subjects

This clinical trial investigated the effects of a growth hormone-releasing hormone (GHRH) antagonist on plasma growth hormone (GH) levels in healthy individuals. The results showed that the GHRH antagonist significantly reduced GH secretion, demonstrating the pivotal role of endogenous GHRH in regulating GH release. This finding suggests that GHRH antagonists

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June 26, 2025 No Comments