Intramuscular oxygen-ozone therapy in the treatment of acute back pain with lumbar disc herniation: a multicenter, randomized, double-blind, clinical trial of active and simulated lumbar paravertebral injection

This randomized controlled trial investigates the use of intramuscular oxygen-ozone (O2O3) therapy in treating acute low back pain (LBP) due to lumbar disc herniation. The study included 60 participants, with those receiving active O2O3 therapy showing significant improvements in pain reduction, disability, and reliance on pain medication compared to the