Hyperbaric Oxygen Therapy Alleviates Memory and Motor Impairments Following Traumatic Brain Injury via the Modulation of Mitochondrial-Dysfunction-Induced Neuronal Apoptosis in Rats

This animal study investigated the neuroprotective effects of hyperbaric oxygen therapy (HBOT) in rats with traumatic brain injury (TBI). The results showed that HBOT significantly improved motor and spatial learning performance, reduced cortical neuronal loss, and decreased the apoptosis marker cleaved-Caspase3. Additionally, HBOT preserved mitochondrial respiration functions and modulated glial