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Association of Wearable Device-Measured Vigorous Intermittent Lifestyle Physical Activity with Mortality

This prospective cohort study analyzed data from 25,241 non-exercising adults (mean age 61.8 years) in the UK Biobank to assess the impact of vigorous intermittent lifestyle physical activity (VILPA) on mortality. VILPA, characterized by brief bouts (1–2 minutes) of vigorous activity during daily life, was measured using wearable accelerometers. Over

June 26, 2025 No Comments

Can a bout of exercise harm the human heart?

This commentary discusses a study by Stewart et al. (2016) that examined the effects of acute endurance exercise on cardiac function in recreationally active men. Participants performed two cycling trials: 90 minutes at heavy intensity and 120 minutes at moderate intensity. Findings indicated transient reductions in left and right ventricular

June 26, 2025 No Comments

Compact Arterial Monitoring Device Use in Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): A Simple Validation Study in Swine

This 2024 study evaluated the accuracy of a compact, disposable pressure monitoring device (Compass™) used during partial REBOA procedures in a swine model. Four Yorkshire pigs underwent induced hemorrhagic shock followed by REBOA with the Compass™ transducer. Mean arterial pressures recorded by the device were compared to standard arterial line

June 26, 2025 No Comments

Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension

This 2022 extension of the STEP 1 trial assessed the effects of discontinuing semaglutide 2.4 mg weekly in adults with obesity. After 68 weeks of treatment, participants had lost an average of 17.3% of their body weight. One year post-withdrawal, they regained approximately two-thirds of this weight loss, resulting in

June 26, 2025 No Comments

Bone Health After Exercise Alone, GLP-1 Receptor Agonist Treatment, or Combination Treatment: A Secondary Analysis of a Randomized Clinical Trial

This 2024 secondary analysis of a randomized clinical trial examined the effects of exercise, GLP-1 receptor agonist (liraglutide) treatment, and their combination on bone health in adults with obesity. After an initial 8-week low-calorie diet, 195 participants were randomized into four groups: exercise alone, liraglutide alone, combination of both, or

June 26, 2025 No Comments

Drug-induced noninfectious myocarditis: a disproportionality analysis of the FAERS database

This 2025 study conducted a disproportionality analysis using the FDA Adverse Event Reporting System (FAERS) to identify drugs associated with noninfectious myocarditis. Analyzing data from 2004 to 2024, the researchers found 10,763 reports of noninfectious myocarditis. The top five drugs with the highest reporting odds ratios (RORs) were phendimetrazine tartrate

June 26, 2025 No Comments

Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study

This randomized controlled trial, published in the Journal of the International Society of Sports Nutrition (2016, PMID: 26900386), investigated the effects of L-citrulline supplementation on cycling performance in healthy trained male cyclists. The study used a double-blind, placebo-controlled, two-way crossover design, where participants received either L-citrulline or a placebo. Results

Oral arginine improves blood pressure in renal transplant and hemodialysis patients

The study titled Oral Arginine Improves Blood Pressure in Renal Transplant and Hemodialysis Patients (JPEN J Parenter Enteral Nutr, 2001, PMID: 11434650) is a clinical trial examining the effects of oral arginine supplementation on blood pressure in hypertensive renal transplant and hemodialysis patients. Results showed that oral arginine, with or

Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early stage breast cancer

The study titled "Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early-stage breast cancer" (PMID: 28826699), published in Clinical Nutrition in 2018, examined the impact of major surgery on arginine metabolism in early-stage breast cancer patients. This observational study found that surgery

l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans

The study titled "L-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans" (Journal of Applied Physiology, 2015, PMID: 26023227) examined the effects of short-term L-citrulline (Cit) supplementation on blood pressure, oxygen uptake (V̇O2) kinetics, and exercise performance in healthy adults. This randomized controlled trial found that Cit

Endogenous flux of nitric oxide: Citrulline is preferred to Arginine

The article "Endogenous flux of nitric oxide: Citrulline is preferred to Arginine" (Acta Physiol (Oxf), 2021, PMID: 33089645) reviews the comparative effectiveness of citrulline versus arginine supplementation in enhancing nitric oxide (NO) production. Due to arginine's significant first-pass metabolism in the splanchnic region, its systemic availability is limited, making citrulline

Effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide synthesis in preeclampsia

This randomized controlled trial examined the effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide (NO) synthesis in preeclamptic women. Conducted with 61 participants, the study found that those receiving 3 grams of l-arginine daily for three weeks experienced significant reductions in systolic (134.2 ± 2.9

Arginine enhances wound healing and lymphocyte immune responses in humans

This observational study examined the effects of arginine supplementation on wound healing and immune function in 36 healthy, nonsmoking adults. Results showed that arginine significantly increased collagen deposition in wounds (p < 0.001) and enhanced lymphocyte proliferation, suggesting improved immune response. The proposed mechanism involves arginine’s role as a precursor

Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence

This in vitro study examined the effects of L-arginine and L-citrulline supplementation on endothelial cell aging, finding that these amino acids successfully delayed endothelial senescence by enhancing nitric oxide production, which plays a crucial role in vascular function. The results suggest potential therapeutic benefits for cardiovascular health and the prevention

Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance

This randomized controlled trial examined the effects of acute L-arginine supplementation on oxygen consumption during moderate-intensity exercise and high-intensity exercise tolerance. Results showed a 7% reduction in steady-state oxygen uptake (VO₂) during moderate-intensity exercise (P < 0.05) and an increased time to exhaustion during high-intensity exercise (707 ± 232 vs.