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Association of Wearable Device-Measured Vigorous Intermittent Lifestyle Physical Activity with Mortality

This prospective cohort study analyzed data from 25,241 non-exercising adults (mean age 61.8 years) in the UK Biobank to assess the impact of vigorous intermittent lifestyle physical activity (VILPA) on mortality. VILPA, characterized by brief bouts (1–2 minutes) of vigorous activity during daily life, was measured using wearable accelerometers. Over

June 26, 2025 No Comments

Can a bout of exercise harm the human heart?

This commentary discusses a study by Stewart et al. (2016) that examined the effects of acute endurance exercise on cardiac function in recreationally active men. Participants performed two cycling trials: 90 minutes at heavy intensity and 120 minutes at moderate intensity. Findings indicated transient reductions in left and right ventricular

June 26, 2025 No Comments

Compact Arterial Monitoring Device Use in Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): A Simple Validation Study in Swine

This 2024 study evaluated the accuracy of a compact, disposable pressure monitoring device (Compass™) used during partial REBOA procedures in a swine model. Four Yorkshire pigs underwent induced hemorrhagic shock followed by REBOA with the Compass™ transducer. Mean arterial pressures recorded by the device were compared to standard arterial line

June 26, 2025 No Comments

Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension

This 2022 extension of the STEP 1 trial assessed the effects of discontinuing semaglutide 2.4 mg weekly in adults with obesity. After 68 weeks of treatment, participants had lost an average of 17.3% of their body weight. One year post-withdrawal, they regained approximately two-thirds of this weight loss, resulting in

June 26, 2025 No Comments

Bone Health After Exercise Alone, GLP-1 Receptor Agonist Treatment, or Combination Treatment: A Secondary Analysis of a Randomized Clinical Trial

This 2024 secondary analysis of a randomized clinical trial examined the effects of exercise, GLP-1 receptor agonist (liraglutide) treatment, and their combination on bone health in adults with obesity. After an initial 8-week low-calorie diet, 195 participants were randomized into four groups: exercise alone, liraglutide alone, combination of both, or

June 26, 2025 No Comments

Drug-induced noninfectious myocarditis: a disproportionality analysis of the FAERS database

This 2025 study conducted a disproportionality analysis using the FDA Adverse Event Reporting System (FAERS) to identify drugs associated with noninfectious myocarditis. Analyzing data from 2004 to 2024, the researchers found 10,763 reports of noninfectious myocarditis. The top five drugs with the highest reporting odds ratios (RORs) were phendimetrazine tartrate

June 26, 2025 No Comments

Treatment of Brittle Fingernails and Onychoschizia With Biotin: Scanning Electron Microscopy

This study examined the impact of biotin on brittle nails and onychoschizia, revealing that biotin supplementation resulted in a 25% increase in nail thickness and improved surface appearance, reducing brittleness. The research involved 32 participants, including 10 controls and 8 biotin-treated patients. Biotin enhances keratin production, improving nail health without

The Role of Vitamins and Minerals in Hair Loss: A Review

This systematic review examines the impact of vitamins and minerals on hair loss, emphasizing the importance of nutrients like iron, zinc, and vitamins A, B, C, D, and E. Deficiencies in these micronutrients can contribute to alopecia, and correcting them may help prevent or treat hair loss. The review suggests

Oxidation events and skin aging

This review examines how oxidative stress, primarily caused by UV exposure, contributes to skin aging, including the degradation of collagen and the formation of reactive oxygen and nitrogen species. It emphasizes the skin’s adaptive response to oxidative stress and the role of antioxidants in mitigating damage. Understanding these mechanisms is

https://pubmed.ncbi.nlm.nih.gov/31955162/

This review article explores the dynamic nature of wound healing, emphasizing that the traditional phases—inflammation, proliferation, and remodeling—overlap and should be addressed simultaneously for optimal recovery. It highlights dexpanthenol as an effective agent across all healing stages, promoting fibroblast proliferation, re-epithelialization, and anti-inflammatory effects. The study underscores the importance of

Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome

This review discusses the benefits of oral supplementation with compounds like collagen, astaxanthin, and zinc in improving skin health and preventing aging. These compounds support skin regeneration, reduce wrinkles, and improve hydration and elasticity. The study highlights how nutrition can complement topical treatments, making it a useful addition to skincare

Systemic dexpanthenol as a novel treatment for female pattern hair loss

This study investigates the use of dexpanthenol (DXP) as a treatment for female pattern hair loss (FPHL). The treatment showed a statistically significant improvement in the Dermatologic Life Quality Index (DLQI), with 57.1% of participants reporting satisfaction with their hair appearance. No adverse effects were noted, and laboratory results did

Prospective Study of Biotin Treatment in Patients With Erythema Due to Gefitinib or Erlotinib

This study examined biotin as a treatment for skin rashes caused by EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib, in patients with non-small cell lung cancer (NSCLC). Four patients who were unresponsive to steroid treatments showed improvement after taking biotin, with two able to continue EGFR-TKI therapy.

Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters

This cohort study evaluated the effects of isotretinoin on skin and hair health, highlighting that biotin supplementation improved hair growth, increasing anagen hair and decreasing telogen hair (P=0.034, P=0.003). While isotretinoin reduced skin hydration, both groups saw decreased skin sebum. This suggests biotin could help mitigate isotretinoin's adverse effects on

Efficacy of intramuscular injections of biotin and dexpanthenol in the treatment of diffuse hair loss: A randomized, double-blind controlled study comparing two brands

This randomized controlled trial investigated the effects of biotin and dexpanthenol injections in treating diffuse hair loss. Over six weeks, both treatments showed significant improvement in hair density and reduced hair fall (p