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Can a bout of exercise harm the human heart?

This commentary discusses a study by Stewart et al. (2016) that examined the effects of acute endurance exercise on cardiac function in recreationally active men. Participants performed two cycling trials: 90 minutes at heavy intensity and 120 minutes at moderate intensity. Findings indicated transient reductions in left and right ventricular

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June 26, 2025 No Comments

Compact Arterial Monitoring Device Use in Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): A Simple Validation Study in Swine

This 2024 study evaluated the accuracy of a compact, disposable pressure monitoring device (Compass™) used during partial REBOA procedures in a swine model. Four Yorkshire pigs underwent induced hemorrhagic shock followed by REBOA with the Compass™ transducer. Mean arterial pressures recorded by the device were compared to standard arterial line

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June 26, 2025 No Comments

Bone Health After Exercise Alone, GLP-1 Receptor Agonist Treatment, or Combination Treatment: A Secondary Analysis of a Randomized Clinical Trial

This 2024 secondary analysis of a randomized clinical trial examined the effects of exercise, GLP-1 receptor agonist (liraglutide) treatment, and their combination on bone health in adults with obesity. After an initial 8-week low-calorie diet, 195 participants were randomized into four groups: exercise alone, liraglutide alone, combination of both, or

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June 26, 2025 No Comments

Hibiscus sabdariffa extract inhibits obesity and fat accumulation, and improves liver steatosis in humans

This 2014 randomized controlled trial assessed the effects of Hibiscus sabdariffa extract (HSE) on obesity and liver steatosis in overweight individuals (BMI ≥27). Over 12 weeks, participants consuming HSE exhibited significant reductions in body weight, BMI, body fat, waist-to-hip ratio, and serum free fatty acids compared to controls. Imaging studies
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Metabolaid® Combination of Lemon Verbena and Hibiscus Flower Extract Prevents High-Fat Diet-Induced Obesity through AMP-Activated Protein Kinase Activation

This 2018 preclinical study investigated the effects of Metabolaid®, a combination of lemon verbena and hibiscus flower extracts, on obesity and metabolic parameters in high-fat diet-induced obese mice. The treatment led to significant reductions in body weight, white adipose tissue, and liver weight. Improvements were observed in serum and hepatic
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Iodine and Iodine Deficiency: A Comprehensive Review of a Re-Emerging Issue

This 2022 review highlights the resurgence of iodine deficiency in industrialized nations, including the U.S., due to declining iodine intake from changes in dietary patterns and food manufacturing practices. Despite historical success with salt iodization programs, inconsistent policies and reduced use of iodized salt have led to mild-to-moderate deficiencies. The
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Correction: Serum 25-Hydroxyvitamin D Concentrations ≥40 ng/ml Are Associated with >65% Lower Cancer Risk: Pooled Analysis of Randomized Trial and Prospective Cohort Study

This 2018 correction pertains to the 2016 study that pooled data from a randomized clinical trial and a prospective cohort to assess the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and cancer risk in women aged 55 and older. The original analysis demonstrated that women with serum 25(OH)D concentrations ≥40
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Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial

This 2023 randomized, double-blind, placebo-controlled trial investigated whether monthly high-dose vitamin D supplementation (60,000 IU) reduces major cardiovascular events (MACE) in adults aged 60–84 years. Over a median follow-up of 5 years, the study found a 9% reduction in MACE incidence in the vitamin D group compared to placebo (hazard
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Vitamin D Supplementation and Sleep: A Systematic Review and Meta-Analysis of Intervention Studies

This 2022 systematic review and meta-analysis evaluated the effects of vitamin D supplementation (VDS) on sleep quality, quantity, and disorders. Analyzing data from multiple randomized controlled trials, the study found that VDS significantly improved sleep quality, as evidenced by a notable decrease in Pittsburgh Sleep Quality Index (PSQI) scores (mean
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Contribution of Dietary Oxalate and Oxalate Precursors to Urinary Oxalate Excretion

This 2020 review examines the roles of dietary oxalate and its precursors in urinary oxalate excretion and the formation of calcium oxalate kidney stones. It highlights that dietary oxalate can contribute up to 50% of urinary oxalate levels, with the remainder arising from endogenous synthesis, notably from ascorbic acid (vitamin
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Correction: The UroLift implant: mechanism behind rapid and durable relief from prostatic obstruction

This 2022 correction pertains to the original article discussing the UroLift implant, a minimally invasive treatment for benign prostatic hyperplasia (BPH). The UroLift system employs small implants to retract prostatic tissue, thereby relieving urethral obstruction without cutting or removing tissue. This approach offers rapid symptom relief and preserves sexual function.
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Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of Dementia With Lewy Bodies in Men

This 2024 retrospective cohort study analyzed data from over 600,000 men to assess whether the use of glycolysis-enhancing α1-adrenergic receptor antagonists—terazosin, doxazosin, or alfuzosin (Tz/Dz/Az)—is associated with a reduced risk of developing dementia with Lewy bodies (DLB). Compared to men taking tamsulosin or 5α-reductase inhibitors (5ARIs), those on Tz/Dz/Az had
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