Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of Dementia With Lewy Bodies in Men

This 2024 retrospective cohort study analyzed data from over 600,000 men to assess whether the use of glycolysis-enhancing α1-adrenergic receptor antagonists—terazosin, doxazosin, or alfuzosin (Tz/Dz/Az)—is associated with a reduced risk of developing dementia with Lewy bodies (DLB). Compared to men taking tamsulosin or 5α-reductase inhibitors (5ARIs), those on Tz/Dz/Az had