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Association of Wearable Device-Measured Vigorous Intermittent Lifestyle Physical Activity with Mortality

This prospective cohort study analyzed data from 25,241 non-exercising adults (mean age 61.8 years) in the UK Biobank to assess the impact of vigorous intermittent lifestyle physical activity (VILPA) on mortality. VILPA, characterized by brief bouts (1–2 minutes) of vigorous activity during daily life, was measured using wearable accelerometers. Over

June 26, 2025 No Comments

Can a bout of exercise harm the human heart?

This commentary discusses a study by Stewart et al. (2016) that examined the effects of acute endurance exercise on cardiac function in recreationally active men. Participants performed two cycling trials: 90 minutes at heavy intensity and 120 minutes at moderate intensity. Findings indicated transient reductions in left and right ventricular

June 26, 2025 No Comments

Compact Arterial Monitoring Device Use in Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): A Simple Validation Study in Swine

This 2024 study evaluated the accuracy of a compact, disposable pressure monitoring device (Compass™) used during partial REBOA procedures in a swine model. Four Yorkshire pigs underwent induced hemorrhagic shock followed by REBOA with the Compass™ transducer. Mean arterial pressures recorded by the device were compared to standard arterial line

June 26, 2025 No Comments

Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension

This 2022 extension of the STEP 1 trial assessed the effects of discontinuing semaglutide 2.4 mg weekly in adults with obesity. After 68 weeks of treatment, participants had lost an average of 17.3% of their body weight. One year post-withdrawal, they regained approximately two-thirds of this weight loss, resulting in

June 26, 2025 No Comments

Bone Health After Exercise Alone, GLP-1 Receptor Agonist Treatment, or Combination Treatment: A Secondary Analysis of a Randomized Clinical Trial

This 2024 secondary analysis of a randomized clinical trial examined the effects of exercise, GLP-1 receptor agonist (liraglutide) treatment, and their combination on bone health in adults with obesity. After an initial 8-week low-calorie diet, 195 participants were randomized into four groups: exercise alone, liraglutide alone, combination of both, or

June 26, 2025 No Comments

Drug-induced noninfectious myocarditis: a disproportionality analysis of the FAERS database

This 2025 study conducted a disproportionality analysis using the FDA Adverse Event Reporting System (FAERS) to identify drugs associated with noninfectious myocarditis. Analyzing data from 2004 to 2024, the researchers found 10,763 reports of noninfectious myocarditis. The top five drugs with the highest reporting odds ratios (RORs) were phendimetrazine tartrate

June 26, 2025 No Comments

Hydrolyzed Collagen—Sources and Applications

This 2019 review article explores hydrolyzed collagen (HC), a group of peptides with low molecular weight (3–6 kDa) obtained through enzymatic hydrolysis in acidic or alkaline media. HC can be extracted from various sources, including bovine, porcine, and marine origins. Marine-derived HC, particularly from fish skin, scales, and bones, has

The Effects of High-Protein Diets on Kidney Health and Longevity

This 2020 review examines the impact of high-protein diets on kidney function and longevity. High dietary protein intake can cause intraglomerular hypertension, leading to kidney hyperfiltration, glomerular injury, and proteinuria. While high-protein diets are popular for weight loss and type 2 diabetes management, evidence suggests that they may worsen renal

Metabolic effects of high-protein diets

This 2007 review examines the metabolic impacts of high-protein diets, particularly in weight-stable individuals. Findings indicate that higher protein intake is associated with lower blood pressure and, in diabetic patients, reduced glycosylated hemoglobin levels. However, the long-term effects on atherosclerosis risk remain unclear due to limited and conflicting epidemiological data.

Weight loss without losing muscle mass in pre-obese and obese subjects induced by a high-soy-protein diet

This 2004 randomized controlled trial evaluated the effects of a high-soy-protein, low-fat diet on body composition in overweight and obese individuals. Ninety participants with a BMI between 27.5 and 35 were assigned to one of three groups: lifestyle education only (LE-G), soy-based diet without exercise (SD-G), or soy-based diet with

When a calorie isn’t just a calorie: a revised look at nutrition in critically ill patients with sepsis and acute kidney injury

This 2022 review examines the complexities of nutritional management in critically ill patients with sepsis and acute kidney injury (AKI). It highlights that sepsis induces unique metabolic changes, such as activation of fasting metabolism, which may be protective. Traditional nutrition strategies, often based on inaccurate caloric estimates and not accounting

Improved Function With Enhanced Protein Intake per Meal: A Pilot Study of Weight Reduction in Frail, Obese Older Adults

This 2016 randomized controlled trial assessed the impact of meal-based protein enhancement on weight loss and physical function in 67 obese adults aged ≥60 with functional limitations. Participants were assigned to either a traditional weight loss diet or one with >30g protein per meal. Both groups experienced significant weight loss

Mitigating the Health Risks of Dining Out: The Need for Standardized Portion Sizes in Restaurants

This 2014 commentary by Cohen and Story highlights the public health risks associated with oversized restaurant portions, which contribute to obesity and diet-related chronic diseases. The authors argue that most diners are unable to accurately assess caloric content, and existing calorie labeling is often ineffective. They propose implementing standardized portion

Impact of weight bias and stigma on quality of care and outcomes for patients with obesity

This 2015 review critically examines empirical evidence on obesity stigma's effects on healthcare quality and patient outcomes. The authors found that many healthcare providers harbor negative attitudes and stereotypes toward individuals with obesity, influencing their perceptions, judgments, and interactions. Such biases can lead to suboptimal care, including misdiagnoses, inadequate treatment,

Parental Communication About Body Weight and Adolescent Health: The Role of Positive and Negative Weight-Related Comments

This 2023 study examined how positive and negative weight-related comments from mothers and fathers affect adolescent health and well-being. Surveying 2,032 U.S. adolescents aged 10–17, researchers found that frequent negative comments from parents were linked to higher levels of depression, unhealthy weight control behaviors, and weight bias internalization. Conversely, positive