This retrospective cohort study assessed the impact of body mass index (BMI) variation on recurrence risk in women with early-stage breast cancer. The analysis revealed that a BMI increase exceeding 5.71% post-diagnosis was significantly associated with higher recurrence rates. Additional factors linked to increased recurrence included age under 55 years,
This 2014 review by Apovian et al. in Nature Reviews Endocrinology provides a comprehensive overview of evidence-based strategies for obesity treatment, emphasizing the importance of individualized approaches. The authors discuss lifestyle interventions, pharmacotherapy, and bariatric surgery, highlighting that while lifestyle modifications are foundational, they often yield modest weight loss and
This study compared the effects of Myo-Inositol and oral contraceptives (OCPs) on lean PCOS adolescents, focusing on hormonal and metabolic improvements. The results showed that Myo-Inositol alone was effective in improving metabolic and hormonal outcomes, especially in the younger age group (13-16 years), where it also reduced weight and BMI.
This study explores the neuroprotective effects of curcumin, a polyphenol from turmeric, in an animal model of Alzheimer’s disease (AD). The results indicate that curcumin treatment improved cognitive function, reduced amyloid plaque deposition by about 50%, and exhibited antioxidant and anti-inflammatory properties. These effects suggest curcumin could be a promising
This systematic review and meta-analysis evaluated the effects of l-carnitine supplementation on weight management in overweight and obese adults, analyzing 37 randomized controlled trials with a total of 2,292 participants. The findings showed that l-carnitine supplementation led to a significant reduction in body weight (-1.21 kg, P < 0.001), BMI
This meta-analysis reviewed data from nine randomized controlled trials with 911 participants to assess the effects of L-carnitine supplementation on weight loss. The findings indicate that L-carnitine supplementation led to a statistically significant weight reduction, with participants losing an average of 1.33 kg more than control groups (p=0.005). However, there
This systematic review evaluated the effects of herbal medicine on hypothyroidism by analyzing randomized controlled trials (RCTs), with a focus on Nigella sativa L. Four studies with 186 participants were included. Key findings showed that Nigella sativa significantly reduced weight, body mass index (BMI), thyroid-stimulating hormone (TSH), and increased T3
The study “Growth hormone administration stimulates energy expenditure and extrathyroidal conversion of thyroxine to triiodothyronine in a dose-dependent manner and suppresses circadian thyrotrophin levels: studies in GH-deficient adults” examines the effects of growth hormone (GH) therapy on metabolic processes and thyroid function in adults with GH deficiency. The findings indicate
This study examined the effect of testosterone on muscle mass and protein synthesis. The results showed that testosterone administration led to a significant reduction in leucine oxidation by 17%, indicating enhanced muscle protein synthesis. However, there were no significant changes in whole-body protein synthesis or muscle fiber diameter. These findings
