This 2019 letter addresses concerns raised about the long-term use of phentermine for weight management. The authors acknowledge existing gaps in knowledge regarding the safety and efficacy of extended phentermine use but highlight emerging evidence suggesting its potential benefits. They reference observational studies indicating that prolonged phentermine therapy may lead
This 2015 guideline by the Endocrine Society provides evidence-based recommendations for the pharmacological treatment of obesity. It emphasizes that lifestyle interventions—diet, exercise, and behavioral modifications—should be the foundation of obesity management for individuals with a BMI ≥25 kg/m². Pharmacotherapy is recommended as an adjunct for patients with a BMI ≥27
This 2004 case series examines the clinical experiences of eight adult patients who utilized pharmacotherapy for obesity management over a period exceeding 10 years. The medications used included agents such as phentermine and sibutramine. Patients reported sustained weight loss, perceived benefits, and an absence of significant side effects. Notably, there
This 12-week randomized, double-blind, placebo-controlled study assessed the effects of Coleus forskohlii (CF) supplementation on body composition and hematological profiles in 23 mildly overweight women. Participants received either 250 mg of 10% CF extract twice daily or a placebo. The CF group showed a trend toward mitigating weight gain, with
This 2014 cross-sectional study assessed the association between breakfast consumption frequency and health parameters among adults. Findings indicated that individuals who frequently consumed breakfast had significantly lower BMI levels compared to infrequent breakfast eaters (χ² = 4.74, P < 0.05). The study concludes that regular breakfast consumption is linked to
This umbrella review analyzed 19 meta-analyses and 16 intervention trials to evaluate the effectiveness of various diets on weight management and diabetes remission in adults with type 2 diabetes. Very low energy diets (VLEDs) providing 400–500 kcal/day for 8–12 weeks resulted in the greatest weight loss, averaging 6.6 kg more
These comprehensive guidelines, developed by AACE and ACE, provide evidence-based recommendations for the medical care of patients with obesity. The guidelines address nine broad clinical questions, resulting in 123 recommendations encompassing 160 specific statements. Key areas include screening, diagnosis, clinical evaluation, treatment options, therapy selection, and treatment goals. The guidelines
This review examines the impact of “weight-friendly” pharmacotherapies in the management of type 2 diabetes mellitus (T2DM), emphasizing the importance of considering the weight effects of different treatment regimens. It highlights that certain antidiabetic agents, such as metformin, GLP-1 receptor agonists, and SGLT2 inhibitors, are associated with weight neutrality or
This comprehensive review addresses the intertwined relationship between obesity and type 2 diabetes mellitus (T2DM), emphasizing the importance of weight management throughout the disease course. It highlights that obesity not only increases the risk of developing T2DM but also exacerbates its complications. The article discusses various interventions, including lifestyle modifications
This retrospective cohort study assessed the impact of body mass index (BMI) variation on recurrence risk in women with early-stage breast cancer. The analysis revealed that a BMI increase exceeding 5.71% post-diagnosis was significantly associated with higher recurrence rates. Additional factors linked to increased recurrence included age under 55 years,
