This 2007 review article critically examines the long-term efficacy of calorie-restricting diets in treating obesity. The authors found that one-third to two-thirds of dieters regain more weight than they initially lost, highlighting the limited sustainability of such interventions. Methodological issues in existing studies, such as low follow-up rates and reliance
This 2015 randomized controlled trial investigated the effects of liraglutide, a GLP-1 receptor agonist, on leptin dynamics during weight loss maintenance in 52 healthy obese individuals. After achieving a 12% weight loss through a low-calorie diet, participants were randomized to receive liraglutide (1.2 mg/day) or no additional treatment for 52
This large-scale European randomized controlled trial (DiOGenes study) investigated the effects of diets varying in protein content and glycemic index (GI) on weight-loss maintenance. After an initial 8-week low-calorie diet, 773 overweight adults who achieved ≥8% weight loss were randomized to one of five ad libitum diets for 26 weeks:
