Well Referenced

Tag: VEGF

Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine

This systematic review explores the neurotrophic mechanisms underlying ketamine’s rapid and sustained antidepressant effects, particularly in treatment-resistant depression. Ketamine increases brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) in the medial prefrontal cortex and hippocampus, promoting synaptogenesis and neurogenesis. These actions reverse the neuronal atrophy commonly observed in

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June 26, 2025 No Comments

Role of neurotrophic and growth factors in the rapid and sustained antidepressant actions of ketamine

This 2023 review article explores the rapid and sustained antidepressant effects of ketamine, focusing on its modulation of neurotrophic and growth factors such as brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and insulin-like growth factor 1 (IGF-1). Ketamine rapidly enhances BDNF and VEGF expression in the prefrontal cortex

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June 26, 2025 No Comments

Intrinsic markers of tumour hypoxia and angiogenesis in localised prostate cancer and outcome of radical treatment: a retrospective analysis of two randomised radiotherapy trials and one surgical cohort study

A cohort study published in Lancet Oncology (2008) examined the role of tumor hypoxia and angiogenesis markers in predicting the outcome of radical treatments for localized prostate cancer. The study found that high expression levels of VEGF and HIF-1α were linked to shorter biochemical failure-free survival in both radiotherapy and

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June 26, 2025 No Comments

Antioxidant Response of Chronic Wounds to Hyperbaric Oxygen Therapy

This observational study evaluated the effects of hyperbaric oxygen therapy (HBOT) on plasma antioxidant defenses and wound healing in 14 patients with chronic non-healing wounds over 20 HBOT sessions. The results showed enhanced antioxidant defenses, increased angiogenesis through elevated VEGF and IL-6 levels, improved vascular tone by decreasing endothelin-1 levels,

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June 26, 2025 No Comments