Well Referenced

Tag: thyroid function

Effect of Seasonal Changes on the Transition Between Subclinical Hypothyroid and Euthyroid Status

This 2013 retrospective longitudinal study analyzed 1,751 individuals with subclinical hypothyroidism and 28,096 euthyroid subjects over a median follow-up of 36 months to assess the impact of seasonal variations on thyroid function. Findings revealed a biphasic pattern in TSH levels, increasing during winter-spring and decreasing in summer-fall. Notably, 57.9% of

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June 26, 2025 No Comments

Depressive Symptoms in Patients with Subclinical Hypothyroidism—The Effect of Treatment with Levothyroxine: A Double-Blind Randomized Clinical Trial

This 2015 double-blind, randomized, placebo-controlled trial assessed whether levothyroxine treatment improves depressive symptoms in 60 adults with subclinical hypothyroidism. Participants were assigned to receive either levothyroxine or placebo for 12 weeks. Depression levels were measured using the Beck Depression Inventory (BDI), which includes somatic and affective subscales. The levothyroxine group

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June 26, 2025 No Comments

TSH Cut-Off Point Based on Depression in Hypothyroid Patients

This 2017 cross-sectional study investigated the association between thyroid-stimulating hormone (TSH) levels and depression in 174 hypothyroid patients on stable levothyroxine therapy with TSH values ranging from 0.5 to 5 mIU/L. Depression severity was measured using the Beck Depression Inventory (BDI). Receiver operating characteristic (ROC) curve analysis identified a TSH

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June 26, 2025 No Comments

Nutrition and thyroid disease

The study examines the role of nutrition in thyroid disease management, focusing on the impact of essential micronutrients such as iodine, selenium, iron, zinc, and vitamins B12, D3, and A on thyroid function. It highlights the benefits of the Mediterranean diet in improving immune, endocrine, and biomolecular responses in thyroiditis

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June 26, 2025 No Comments

Thyroid-Gut-Axis: How Does the Microbiota Influence Thyroid Function?

The article “Thyroid-Gut-Axis: How Does the Microbiota Influence Thyroid Function?” explores the relationship between gut microbiota and thyroid health, emphasizing how a balanced gut microbiome supports both immune function and thyroid regulation. Autoimmune thyroid diseases (AITDs) like Hashimoto’s thyroiditis and Graves’ disease frequently coexist with gastrointestinal disorders such as celiac

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June 26, 2025 No Comments

Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document

The article titled “Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document” examines the inconsistent benefits of levothyroxine (LT4) and liothyronine (LT3) combination therapy for hypothyroidism, despite its widespread use due to patient-reported benefits. A joint conference by the American, British, and European Thyroid Associations reviewed clinical evidence

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June 26, 2025 No Comments

A review of the safety of triiodothyronine in combination with levothyroxine for the management of hypothyroidism

This systematic review evaluates the safety of combining levothyroxine (LT4) and triiodothyronine (T3) for hypothyroidism treatment, particularly assessing the risk of thyrotoxicosis. Despite mixed evidence on clinical benefits, some patients report symptom improvement with LT4+T3 therapy. The review finds that safety concerns, especially regarding thyrotoxicosis, are minimal when LT4:T3 ratios

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June 26, 2025 No Comments

[Effects of various contraceptives on laboratory parameters in diagnosis of thyroid gland function with special reference to the free hormones FT4 and FT3]

This observational study examined the effects of various contraceptives on laboratory assessments of thyroid function, focusing on free thyroxine (FT4) and free triiodothyronine (FT3) levels. The findings indicate that contraceptive use, particularly those containing estrogen, can influence thyroid hormone measurements by increasing thyroid-binding globulin levels, potentially altering free hormone concentrations.

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June 26, 2025 No Comments

Assessment of thyroid function

This article discusses the clinical assessment of thyroid function, focusing on the measurement of free T4, T3, and TSH levels. It explains how these hormone levels correlate with thyroid activity, with lower levels of T4 and elevated TSH indicating hypothyroidism, and higher levels of T4 and T3 signaling hyperthyroidism. The

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June 26, 2025 No Comments