Well Referenced

Tag: therapeutic potential

Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress

This 2021 study by Magaquian et al. investigates the effects of phosphatidylcholine (PtdCho) on neural stem cells (NSCs) under inflammatory conditions. The researchers found that while inflammation did not affect NSC proliferation, it led to aberrant neuronal differentiation, resulting in dystrophic, non-functional neurons. Supplementation with PtdCho enhanced neuronal differentiation even

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June 26, 2025 No Comments

EDTA Chelation Therapy for the Treatment of Neurotoxicity

This 2019 review examines the therapeutic potential of calcium disodium ethylenediaminetetraacetic acid (EDTA) chelation therapy in mitigating neurotoxicity caused by toxic metals, pesticides, air pollution, radiation, and certain drugs. EDTA chelation therapy may exert neuroprotective effects by removing toxic metals, reducing oxidative stress, and modulating inflammatory responses. The authors present

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June 26, 2025 No Comments

Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors

This 2021 review examines the pharmacological properties and therapeutic potential of NAD⁺ precursors, including nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), and nicotinic acid (NA). The authors discuss how these compounds enhance NAD⁺ levels, influencing cellular redox states, energy metabolism, and sirtuin activity. The review highlights the role of NAD⁺ in

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June 26, 2025 No Comments

NAD⁺ Deficiency Is a Common Central Pathological Factor of a Number of Diseases and Aging: Mechanisms and Therapeutic Implications

This review article highlights the critical role of nicotinamide adenine dinucleotide (NAD⁺) deficiency in various diseases and aging processes. It discusses how NAD⁺ deficiency is observed in models of cerebral ischemia, myocardial ischemia, diabetes, and aging. The deficiency results from factors like poly(ADP-ribose) polymerase-1 (PARP-1) activation, decreased nicotinamide phosphoribosyltransferase (Nampt)

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June 26, 2025 No Comments

The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential

This 2021 review explores the multifaceted role of nicotinamide adenine dinucleotide (NAD⁺) in cardiovascular diseases (CVDs). NAD⁺ is integral to metabolic pathways, redox balance, and immune modulation. The article discusses how NAD⁺ influences cardiovascular health through sirtuin-dependent and independent mechanisms, affecting aging, inflammation, and oxidative stress. It highlights the potential

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June 26, 2025 No Comments

Anti-inflammatory effects of ozonated water in an experimental mouse model

This study evaluated the anti-inflammatory effects of ozonated water in a mouse model of acute inflammation induced by lipopolysaccharide (LPS). The results showed that intraperitoneal injection of ozonated water significantly decreased tumor necrosis factor-α (TNF-α) levels and increased superoxide dismutase (SOD) activity, suggesting its potential as an anti-inflammatory agent. Ozonated

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June 26, 2025 No Comments

Health benefits of resveratrol: Evidence from clinical studies

This systematic review evaluates the health benefits and safety of resveratrol, a polyphenolic compound found in plants, based on over 244 clinical trials. Resveratrol has shown promise in improving outcomes for a variety of chronic conditions, including diabetes, obesity, certain cancers, metabolic syndrome, hypertension, Alzheimer’s disease, stroke, cardiovascular diseases, kidney

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June 26, 2025 No Comments

Cannabidiol for the Treatment of Brain Disorders: Therapeutic Potential and Routes of Administration

This study explores the therapeutic potential of cannabidiol (CBD) for brain disorders, focusing on its interaction with multiple brain targets and evaluating alternative drug delivery methods to enhance its efficacy. Oral CBD administration is limited by slow absorption and low bioavailability due to first-pass metabolism, prompting interest in alternative delivery

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June 26, 2025 No Comments

Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders

This systematic review explores the broad therapeutic potential of cannabidiol (CBD) in the treatment of psychiatric disorders such as anxiety, depression, and psychosis. It synthesizes data from multiple in vivo studies and highlights that CBD exerts its beneficial effects through several mechanisms, including facilitating 5-HT1A receptor-mediated neurotransmission, potentiating anandamide-mediated pathways

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June 26, 2025 No Comments

Methylene blue reduces monoamine oxidase expression and oxidative stress in human cardiovascular adipose tissue

This study examined the effect of methylene blue (MB) on oxidative stress and monoamine oxidase (MAO) expression in human cardiovascular adipose tissue, finding that MB significantly reduces oxidative stress markers and MAO expression. These findings suggest that MB could serve as a potential therapeutic option for managing cardiovascular diseases linked

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June 26, 2025 No Comments