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Tag: testosterone replacement therapy

Effects of testosterone on behavior, depression, and cognitive function in older men with mild cognitive loss

A 2004 randomized controlled trial published in the Journal of Gerontology: Biological Sciences and Medical Sciences (PMID: 14718489) examined the effects of testosterone replacement on behavior, depression, and cognitive function in older men with mild cognitive impairment. Over 12 weeks, 11 men aged 73-87 with low bioavailable testosterone levels received

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June 26, 2025 No Comments

Efficacy and safety of testosterone replacement therapy in men with hypogonadism: A meta-analysis study of placebo-controlled trials

A 2016 meta-analysis published in Experimental and Therapeutic Medicine (PMID: 26998003) evaluated the efficacy and safety of testosterone replacement therapy (TRT) in men with hypogonadism, analyzing data from 16 randomized controlled trials. The study found that TRT effectively alleviates symptoms such as low libido, fatigue, and reduced muscle mass while

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June 26, 2025 No Comments

Hypogonadism, ADAM, and hormone replacement

This review article discusses male hypogonadism, or testosterone deficiency syndrome (TDS), a condition characterized by inadequate testosterone production, leading to symptoms such as fatigue, erectile dysfunction, cognitive changes, and altered body composition. It classifies hypogonadism into primary (e.g., genetic disorders like Klinefelter’s syndrome) and secondary causes (e.g., hypothalamic or pituitary

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June 26, 2025 No Comments

Increased frequency of anxiety, depression, quality of life and sexual life in young hypogonadotropic hypogonadal males and impacts of testosterone replacement therapy on these conditions

This observational study examined the impact of testosterone replacement therapy (TRT) on anxiety, depression, quality of life, and sexual function in young males with congenital hypogonadotropic hypogonadism (CHH). The study included 39 CHH patients and 40 healthy controls, revealing that CHH patients had significantly higher anxiety and depression levels and

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June 26, 2025 No Comments

Association between testosterone replacement therapy and cardiovascular outcomes: A meta-analysis of 30 randomized controlled trials

This meta-analysis of 30 randomized controlled trials investigated the impact of testosterone replacement therapy (TRT) on cardiovascular outcomes. It found that TRT did not significantly affect cardiovascular mortality but improved cholesterol levels and reduced systolic blood pressure. However, concerns about long-term cardiovascular risks persist. Providers should monitor cardiovascular health during

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June 26, 2025 No Comments

Blood donation and testosterone replacement therapy

This observational study examined the impact of testosterone replacement therapy (TRT) on hemoglobin levels in 39 male blood donors, revealing that 25% of clinic visits recorded hemoglobin levels ≥180 g/L, and 44% of repeat donors had persistently elevated levels. This suggests that blood donation alone may be insufficient to manage

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June 26, 2025 No Comments