Well Referenced

Tag: Testosterone deficiency

Testosterone deficiency, insulin-resistant obesity and cognitive function

This 2015 review explores the complex interactions between testosterone deficiency, insulin-resistant obesity, and cognitive decline. It highlights how low testosterone levels can exacerbate insulin resistance and promote central adiposity, both of which are linked to increased neuroinflammation and oxidative stress—key contributors to cognitive impairment. Testosterone appears to support cognitive function

Read More »
June 26, 2025 No Comments

Andropause—Lessons from the European Male Ageing Study

This 2014 review summarizes findings from the European Male Ageing Study (EMAS), a multicenter observational study involving over 3,000 men aged 40–79 from eight European countries. EMAS identified late-onset hypogonadism (LOH) as a distinct syndrome defined by the presence of low testosterone levels and three specific sexual symptoms: reduced libido,

Read More »
June 26, 2025 No Comments

Re: Fundamental Concepts Regarding Testosterone Deficiency and Treatment: International Expert Consensus Resolutions

This commentary by Allen D. Seftel addresses the 2016 international expert consensus on testosterone deficiency (TD) and its treatment. Seftel emphasizes the consensus’s key resolutions, which affirm that TD is a significant medical condition affecting male health and quality of life, and that testosterone therapy (TTh) is effective and evidence-based.

Read More »
June 26, 2025 No Comments

Testosterone deficiency: a historical perspective

This comprehensive review traces the understanding of testosterone deficiency from antiquity to modern times. It highlights early observations by Aristotle on castration effects, the 19th-century experiments by Berthold establishing internal secretion concepts, and the self-experiments by Brown-Séquard that popularized organotherapy. The isolation and synthesis of testosterone in 1935 marked a

Read More »
June 26, 2025 No Comments

Guideline of Guidelines: Testosterone Therapy for Testosterone Deficiency

This 2019 review by Salter and Mulhall critically compares testosterone therapy (TTh) guidelines from major international medical societies, including the American Urological Association (AUA), Endocrine Society (ES), European Association of Urology (EAU), and others. The consensus across these guidelines emphasizes that TTh should be reserved for men with confirmed testosterone

Read More »
June 26, 2025 No Comments

Occult prostate cancer in men with low serum testosterone levels

This observational study examined the prevalence of occult prostate cancer in 77 men with low serum testosterone levels, normal digital rectal examination (DRE) results, and prostate-specific antigen (PSA) levels of 4.0 ng/mL or less. Prostate cancer was detected in 14% of participants, with prevalence increasing to 29% in men aged

Read More »
June 26, 2025 No Comments

Symptomatic response rates to testosterone therapy and the likelihood of completing 12 months of therapy in clinical practice

This cohort study evaluates the symptomatic response and adherence to testosterone therapy (TTh) in men with testosterone deficiency. The study involved 127 men, with most reporting improvements in erectile function, libido, energy, and mood within 3 months. By 12 months, 63% of the participants continued therapy with sustained benefits. However,

Read More »
June 26, 2025 No Comments

Testosterone and Cardiovascular Health

The article “Testosterone and Cardiovascular Health” is a literature review that examines the relationship between testosterone therapy and cardiovascular health, focusing on conflicting evidence regarding the cardiovascular risks and benefits of testosterone supplementation. It addresses the ongoing debate about testosterone’s potential to cause cardiovascular events, with some studies suggesting increased

Read More »
June 26, 2025 No Comments

Testosterone and weight loss: the evidence

This review examines the role of testosterone replacement therapy (TRT) in weight loss and body composition improvement in men with testosterone deficiency, particularly those who are overweight or obese. The study shows that TRT leads to significant reductions in fat mass, waist circumference, and BMI, while increasing lean body mass.

Read More »
June 26, 2025 No Comments

Testosterone deficiency and replacement: Myths and realities

This review examines the benefits and misconceptions surrounding testosterone deficiency (hypogonadism) and testosterone replacement therapy (TRT). It highlights the significant health risks associated with testosterone deficiency, such as sexual dysfunction, bone loss, and metabolic syndrome, and argues that TRT can provide substantial benefits, including improved sexual function, overall well-being, and

Read More »
June 26, 2025 No Comments