Well Referenced

Tag: smoking

Sildenafil citrate for erectile dysfunction in men with diabetes and cardiovascular risk factors: a retrospective analysis of pooled data from placebo-controlled trials

This meta-analysis evaluated the efficacy and safety of sildenafil citrate in men with erectile dysfunction (ED) and diabetes mellitus (DM), including those with additional cardiovascular (CV) risk factors. The study pooled data from 11 randomized, double-blind, placebo-controlled trials involving 974 men with DM and ED, randomized to receive either placebo

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June 26, 2025 No Comments

Effect of age, smoking and other lifestyle factors on urinary 7-methylguanine and 8-hydroxydeoxyguanosine

This observational study examined the effects of age, smoking, and other lifestyle factors on urinary levels of 7-methylguanine (m7G) and 8-hydroxydeoxyguanosine (8-OHdG), biomarkers of DNA methylation and oxidative DNA damage, respectively. Analyzing 215 healthy Japanese individuals, the study found that current smokers exhibited significantly higher urinary m7G levels (p <

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June 26, 2025 No Comments

Oxidative stress biomarkers and lifestyles in Japanese healthy people

This observational study investigated the relationship between lifestyle factors and oxidative stress biomarkers in 135 healthy Japanese adults aged 20 to 69 years. The findings showed that smokers had significantly higher urinary 8-hydroxydeoxyguanosine (8-OHdG) levels (p < 0.05), indicating increased oxidative DNA damage, while individuals who engaged in regular physical

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June 26, 2025 No Comments

Health examination results and work environment factors affecting urinary 8-hydroxy-2′-deoxyguanosine levels

This study examined the association between urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels, a biomarker of oxidative stress, and various health and occupational factors in 503 male workers. Findings revealed that higher urinary 8-OHdG levels were linked to high blood sugar and leanness in smokers, while exposure to organic solvents, hydrochloric acid, and

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June 26, 2025 No Comments

Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index

This observational study examined the relationship between oxidative DNA damage, measured by urinary 8-hydroxydeoxyguanosine (8-OHdG) excretion, and lifestyle factors such as smoking, gender, and body mass index (BMI) in 121 healthy individuals aged 25-64. Results showed that smokers had a 50% higher 8-OHdG excretion than non-smokers (p

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June 26, 2025 No Comments

Salivary 8-hydroxyguanine as a lifestyle-related oxidative stress biomarker in workers

This study examined the potential of salivary 8-hydroxyguanine (8-OHGua) as a noninvasive biomarker for oxidative stress in workers. Researchers measured 8-OHGua levels in saliva samples from both smokers and non-smokers, finding that smokers exhibited significantly higher levels, indicating increased oxidative stress. These findings suggest that salivary 8-OHGua could serve as

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June 26, 2025 No Comments

The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged men

This observational study analyzed how smoking, age, relative weight, and dietary intake influence serum levels of adrenal steroids, sex hormones, and sex hormone-binding globulin (SHBG) in 1,241 middle-aged U.S. men. Results showed that smokers had significantly higher levels of DHEA (18%), DHEAS (13%), cortisol (5%), androstenedione (33%), testosterone (9%), DHT

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June 26, 2025 No Comments

Distribution and determinants of C-reactive protein in the older adult population: European Prospective Investigation into Cancer-Norfolk study

This observational study from the EPIC-Norfolk cohort examined the distribution and determinants of C-reactive protein (CRP) levels in 18,586 adults aged 40-79 years, with follow-up measurements in 6,087 individuals over 13 years. Higher CRP levels were associated with older age, female sex, higher BMI, smoking, and physical inactivity, with these

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June 26, 2025 No Comments