Well Referenced

Tag: serotonin

Neurobiologic Basis of Craving for Carbohydrates

This 2014 review examines the multifaceted neurobiological mechanisms underlying carbohydrate cravings. It identifies five key domains: (1) the serotonergic system, where carbohydrate intake can elevate serotonin levels, influencing mood and appetite; (2) palatability and hedonic response, highlighting the rewarding properties of carbohydrates; (3) the motivational system, noting that carbohydrates can

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June 26, 2025 No Comments

Effect of inositol on bulimia nervosa and binge eating

This study explored the effects of inositol on bulimia nervosa and binge eating disorder, finding that 18 g of inositol daily for 6 weeks significantly improved clinical outcomes, including measures on the Global Clinical Impression, Visual Analogue Scale, and Eating Disorders Inventory. Inositol was more effective than the placebo, offering

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June 26, 2025 No Comments

Chronic administration of synthetic cannabidiol induces antidepressant effects involving modulation of serotonin and noradrenaline levels in the hippocampus

This study examined the antidepressant-like effects of chronic administration of synthetic cannabidiol (CBD) in mice. Over seven days, mice received CBD at doses of 10, 30, or 100 mg/kg, and depressive-like behaviors were assessed using the forced swim test (FST). The study found that 100 mg/kg of CBD significantly reduced

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June 26, 2025 No Comments

New insights into the involvement of serotonin and BDNF-TrkB signalling in cannabidiol’s antidepressant effect

This 2024 review investigates the antidepressant mechanisms of cannabidiol (CBD), focusing on its interaction with serotonin and BDNF-TrkB signaling pathways. CBD may exert rapid and sustained antidepressant effects by increasing serotonin release in the prefrontal cortex via action on dorsal raphe nuclei and enhancing BDNF-TrkB signaling, which promotes neuroplasticity. These

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June 26, 2025 No Comments

Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analogues

This animal study evaluated the antidepressant-like effects of methylene blue (MB) and its analogues, methylene green (MG) and others, demonstrating significant reductions in depressive behaviors in rodents. MB and MG showed dose-dependent improvements in depression symptoms, primarily by enhancing mitochondrial function, inhibiting monoamine oxidase (MAO) and nitric oxide synthase (NOS),

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June 26, 2025 No Comments

Methylene blue and its analogues as antidepressant compounds

This review explores the antidepressant and anxiolytic properties of methylene blue (MB) and its analogues. MB exerts its effects through mechanisms such as monoamine oxidase A (MAO-A) inhibition, which increases neurotransmitter levels, and modulation of nitric oxide pathways. These actions suggest MB’s potential as a therapeutic agent for treating mood

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June 26, 2025 No Comments

Understanding the Role of Serotonin in Female Hypoactive Sexual Desire Disorder and Treatment Options

This narrative review explores the neurobiological mechanisms underlying hypoactive sexual desire disorder (HSDD) in women, focusing on the inhibitory role of serotonin in sexual desire. The review highlights that serotonin overactivity may contribute to HSDD by suppressing excitatory pathways involved in sexual function. It discusses pharmacologic treatments targeting serotonin, particularly

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June 26, 2025 No Comments

Designing drugs for the treatment of female sexual dysfunction

The article “Designing drugs for the treatment of female sexual dysfunction” (PMID: 17826689) reviews therapeutic strategies for female sexual dysfunction (FSD), which affects approximately 30% of women and includes issues with desire, arousal, and orgasm. Early treatments, modeled after male erectile dysfunction therapies, have largely been ineffective for women, leading

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June 26, 2025 No Comments